I'll let you in on one of poker, (and life's) secrets fug, You don't have to respond with anything meaningful, you don't have to respond with anything at all. (Silence and a smile will piss them of more than anything anyway)
Let the others concentrate on witty remarks, you just concentrate on the poker
Most of the time I end up doing just that anyway

as I can't think of anything to say.
Fugly I think lots of people with aspergers are attracted to poker because of the maths involved and I would think that there might be quite a few who are very sucessful online but as you say find it more difficult playing live as their reading skills are not so good.
I have learnt through research to reconize the "signs" of aspies and although I dont play live much it is amazing how many I have spotted when I do.
Red summed it up perfect
I hope the successful online players with aspies dont act like dicks live because that would give us a bad name. Last thing anyone needs is to be pigeonholed. That is of course, if there are any.
I try not to rely on physical tells live. I think you learn more through listening to other peoples speech and through betting patterns. Also the fact that I'm not the best at reading people means I could quite often lose a lot of money. I struggle to see the subtle things so try not to rely on them, and my make my decisions how I would online.