This is the HUD setup that I use for heads up

I don't play heads up PLO but in holdem the ones that really jump out as obvious leaks are a high BB VPIP and low aggression factor. Low Cbet is usually a leak too and vs me an overly high flop Cbet is gunna be a leak too, but against most its fine. Mine is usually gunna be >85%
The vast majority of my play is heads up and most of the people that I play heads up don't really play many of the 6max SNGs that I used to. If I do notice that I have a lot of hands on someone and I can't remember having played a lot heads up with them I'll just use session stats. If you double click on the HUD for that player in holdem manager it just gives you the stats for the current session.
tyvm x