Whollyflush put out some good reasons why we can't just call to hit a set here. I'd advocate a call here, sometimes we hit a set, sometimes we can call a street then he gives up, sometimes we call a street then he barrels a K or something and can call again etc. Basically very often we are going to have the best hand postflop and given his 22 hand we don't really have to fold a lot but we manage to keep in a lot of hands we gonna do well against.
Also his 3bet size is altered in the hands (3bets to 500 wth 22, 600 this time) making me think he has it this time, esp given the previous hand.
I'd put greater weight into this being because they are deeper stacked now than a bet sizing tell.
providing you arent doing it 100% of teh time there is nothing wrong taking shots getting 10:1 implied oddds imo
I will always mine at 10/1 implied odds but you don't have that here. Implied odds doesn't mean how big is their stack divided by how much it's costing you. It's how often you get paiiiid when you hit your set. Again agree with whollyflush here, given that he 3 bet 22, our implied odds aren't very good at all here. Implied odds are generally only their whole stack when they have a very strong hand (e.g. a massive nit opens UTG 9 handed is likely JJ+ AK sometimes TT AQ).