Yeah we went to Clearwater and that was a good day out, also there is the Kennedy space centre on the other coast which is well worth a visit.
^^Agree
I've stayed in the Holiday Inn on International Drive twice. That was cool and in close proximity of pretty much everything.
Depends how old your kids are man, if they are young a Disney Hotel might be the way to go, but I've never stayed in one of them or a Villa so can't really advise...