I hope this question makes sense.
Would you say that the correct play in Omaha is less opponent dependant than it is in Hold'em?
I agree with this a huge amount. People in general PLO play in a far more unbalanced style than those in NLHE, even the inexperienced players. The game of course lends itself to that with the fact that hand ranges mean board texture changes are far more important than they are in NLHE. I think the clearest case is value betting, value betting sizes/ranges in PLO don't vary a huge amount vs differing players, in NLH its huge.
Of course there are exceptions to this rule, they are some people you will happily fold second set to in PLO vs a raise but overall I NLHE has much more room to adjust.